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Procaspase-3 activator 1541B

CAS No. 1170689-68-5

Procaspase-3 activator 1541B( Compound 1541B )

Catalog No. M10573 CAS No. 1170689-68-5

Procaspase-3 activator 1541B is a specific, small molecule activator of procaspases-3 with EC50 of 1.3 uM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Procaspase-3 activator 1541B
  • Note
    Research use only, not for human use.
  • Brief Description
    Procaspase-3 activator 1541B is a specific, small molecule activator of procaspases-3 with EC50 of 1.3 uM.
  • Description
    Procaspase-3 activator 1541B is a specific, small molecule activator of procaspases-3 with EC50 of 1.3 uM; shows no activition activity for procaspases-6; shows considerable synergy in activating procaspase-3 in vitro combined with PAC-1, stimulates rapid and dramatic maturation of procaspase-3 in multiple cancer cell lines; effectively reduces tumor burden in a murine lymphoma model combined with PAC-1, but not treated alone.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Compound 1541B
  • Pathway
    Apoptosis
  • Target
    Caspase
  • Recptor
    Caspase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1170689-68-5
  • Formula Weight
    397.39
  • Molecular Formula
    C23H15N3O4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(C(C1=O)=CC2=C(O1)C(O)=CC=C2)NC3=CC=CC(C4=CN5C=CC=CC5=N4)=C3
  • Chemical Name
    8-hydroxy-N-(3-(imidazo[1,2-a]pyridin-2-yl)phenyl)-2-oxo-2H-chromene-3-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wolan DW, et al. Science. 2009 Nov 6;326(5954):853-8. 2. Botham RC, et al. J Am Chem Soc. 2014 Jan 29;136(4):1312-9. 3. Julien O, et al. Nat Chem Biol. 2014 Nov;10(11):969-76.
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